Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 4/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319650 | 0.79 | CACNA2D1 (0.37) | GNAO1CACNA2D1CACNA1BCACNB1GBA1 | |
| SCHEMBL24319188 | 0.74 | NCF1 (0.41) | CACNA2D1CACNA1BCACNB1ACHE | |
| SCHEMBL24319365 | 0.72 | CACNA2D1 (0.36) | GNAO1CACNA2D1CACNA1BCACNB1GBA1 | |
| SCHEMBL14422030 | 0.70 | GBA1 (0.48) | GNAO1CACNA2D1CACNA1BCACNB1GNAI3 | |
| SCHEMBL17257630 | 0.69 | GNAO1 (0.50) | GNAO1CACNA2D1CACNA1BCACNB1GNAI3 | |
| SCHEMBL24319495 | 0.69 | — | — | |
| SCHEMBL2794883 | 0.69 | CACNA2D1 (0.42) | GNAO1CACNA2D1CACNA1BCACNB1GNAI3 | |
| SCHEMBL24319651 | 0.68 | NCF1 (0.38) | CACNA2D1CACNA1BCACNB1ACHE | |
| SCHEMBL24319174 | 0.68 | ACHE (0.38) | GNAO1CACNA2D1CACNA1BCACNB1GNAI3 | |
| Hydrochloric Acid SCHEMBL5573130 | 0.68 | GBA1 (0.47) | GNAO1CACNA2D1CACNA1BCACNB1GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |