Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326314 | 0.89 | MEN1 (0.32) | KMT2AMEN1MAPT | |
| SCHEMBL24326315 | 0.88 | SIGMAR1 (0.39) | ALDH1A1KMT2ASIGMAR1KDM4ELMNA | |
| SCHEMBL24325752 | 0.87 | ALDH1A1 (0.40) | ALDH1A1SIGMAR1KDM4EPDCD1CD274 | |
| SCHEMBL24325734 | 0.80 | PRMT6 (0.35) | ALDH1A1MAPTSIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL24326076 | 0.80 | CXCR4 (0.40) | KMT2AMEN1SIGMAR1 | |
| SCHEMBL24326673 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KMT2AMEN1SIGMAR1LMNA | |
| SCHEMBL24331843 | 0.79 | NR1H2 (0.34) | L3MBTL1 | |
| SCHEMBL24326679 | 0.78 | ALDH1A1 (0.41) | ALDH1A1SIGMAR1POLB | |
| SCHEMBL24326190 | 0.77 | TBK1 (0.42) | KMT2AMEN1MAPT | |
| SCHEMBL29570802 | 0.75 | LMNA (0.48) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |