Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 13/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24325796 | 0.85 | FFAR4 (0.31) | — | |
| SCHEMBL24325821 | 0.82 | GPR119 (0.41) | GPR119MAPT | |
| SCHEMBL24325795 | 0.81 | TBK1 (0.34) | — | |
| SCHEMBL24325177 | 0.77 | HTT (0.35) | — | |
| SCHEMBL24326280 | 0.77 | NR1H2 (0.34) | GPR119NR1H2NR1H3 | |
| SCHEMBL24326293 | 0.76 | SMARCA2 (0.33) | GPR119 | |
| SCHEMBL27012775 | 0.74 | PARP1 (0.32) | — | |
| SCHEMBL24325812 | 0.73 | MAP4K1 (0.39) | — | |
| SCHEMBL24325712 | 0.73 | — | — | |
| SCHEMBL24325710 | 0.73 | HRH3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |