Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | KAT7 | O95251 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 2/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.30 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326280 | 0.88 | NR1H2 (0.34) | SMARCA2SMARCA4PBRM1USP30GPR119 | |
| SCHEMBL24325821 | 0.84 | GPR119 (0.41) | SMARCA2SMARCA4PBRM1GPR119MEN1 | |
| SCHEMBL24326273 | 0.76 | GPR119 (0.37) | GPR119 | |
| SCHEMBL24326160 | 0.75 | NR1I2 (0.30) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL24325770 | 0.75 | TRPV3 (0.35) | USP30TRPV3PARP1MMP1MMP9 | |
| SCHEMBL24325771 | 0.73 | GPR119 (0.33) | USP30GPR119TRPV3PARP1MEN1 | |
| SCHEMBL24326398 | 0.73 | MEN1 (0.37) | USP30TRPV3PARP1MEN1KMT2A | |
| SCHEMBL24326719 | 0.73 | GPR119 (0.34) | USP30GPR119TRPV3PARP1 | |
| SCHEMBL27012855 | 0.73 | MAP3K7 (0.31) | — | |
| SCHEMBL27012691 | 0.72 | GRIN2B (0.36) | PARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |