Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326293 | 0.88 | SMARCA2 (0.33) | SMARCA2SMARCA4PBRM1TRPV3USP30 | |
| SCHEMBL24326160 | 0.86 | NR1I2 (0.30) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL24325821 | 0.84 | GPR119 (0.41) | SMARCA2SMARCA4PBRM1GPR119MEN1 | |
| SCHEMBL24326719 | 0.80 | GPR119 (0.34) | TRPV3USP30PFKFB3GPR119PARP1 | |
| SCHEMBL24326273 | 0.77 | GPR119 (0.37) | NR1H2NR1H3GPR119 | |
| SCHEMBL24325770 | 0.74 | TRPV3 (0.35) | TRPV3USP30PFKFB3PARP1C5AR1 | |
| SCHEMBL24326398 | 0.74 | MEN1 (0.37) | NR1H2NR1H3TRPV3USP30PARP1 | |
| SCHEMBL24326126 | 0.72 | IRAK4 (0.34) | TRPV3MEN1KMT2ANTRK1 | |
| SCHEMBL24326671 | 0.72 | IRAK4 (0.36) | NR1H2NR1H3MEN1KMT2ANTRK1 | |
| SCHEMBL24325812 | 0.71 | MAP4K1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |