Sugi Predict

Sugi Predict / Compounds / SCHEMBL2434019

SCHEMBL2434019

SCHEMBL2434019

CCOC(=O)/C(C)=C/c1cc(F)c(OCc2ccccc2)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR1H4 Q96RI1 1/20 0.52
▸ KMT2A Q03164 3/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ ALDH1A1 P00352 3/20 0.44
▸ THRA P10827 1/20 0.41
▸ THRB P10828 1/20 0.41
▸ BRD4 O60885 1/20 0.40
▸ LMNA P02545 4/20 0.40
▸ PTPN1 P18031 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ FFAR4 Q5NUL3 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ CYP2C9 P11712 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2434020 1.00 NR1H4 (0.52) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL2436006 0.88 NR1H4 (0.52) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL2436007 0.88 NR1H4 (0.52) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL13221558 0.88 NR1H4 (0.52) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL2436026 0.87 NR1H4 (0.51) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL2306116 0.86 AKR1C3 (0.49) KMT2AMEN1ALDH1A1THRATHRB
SCHEMBL2306118 0.86 AKR1C3 (0.49) KMT2AMEN1ALDH1A1THRATHRB
SCHEMBL2301698 0.84 NR1H4 (0.47) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL2301696 0.84 NR1H4 (0.47) NR1H4KMT2AMEN1ALDH1A1THRA
SCHEMBL13286042 0.83 MEN1 (0.47) NR1H4KMT2AMEN1ALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2914580-B1 THIOARYL DERIVATIVES AS GPR120 AGONISTS LG CHEMICAL LTD (KR) 2019-02-20 — — EP disclosed
EP-3114111-B1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 — — EP disclosed
EP-2970182-B1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 JANSSEN PHARMACEUTICA NV (BE) 2017-05-03 — — EP disclosed
US-9447044-B2 Thioaryl derivatives as GPR120 agonists LG LIFE SCIENCES LTD. (KR) 2016-09-20 — — US disclosed
US-20150291527-A1 THIOARYL DERIVATIVES AS GPR120 AGONISTS LG LIFE SCIENCES LTD. (KR) 2015-10-15 — — US disclosed
WO-2015134038-A1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 JANSSEN PHARMACEUTICA NV (BE) 2015-09-11 — — WO disclosed
EP-2914580-A1 THIOARYL DERIVATIVES AS GPR120 AGONISTS LG Life Sciences Ltd. (KR) 2015-09-09 — — EP disclosed
US-9045454-B2 Bicyclic pyrrole derivatives useful as agonists of GPR120 JANSEN PHARMACEUTICA NV (BE) 2015-06-02 — — US disclosed
US-9045454-B2 Bicyclic pyrrole derivatives useful as agonists of GPR120 JANSEN PHARMACEUTICA NV (BE) 2015-06-02 — — US disclosed
US-8912227-B1 Bicyclic pyrrole derivatives useful as agonists of GPR120 JANSSEN PHARMACEUTICA NV (BE) 2014-12-16 — — US disclosed
US-8912227-B1 Bicyclic pyrrole derivatives useful as agonists of GPR120 JANSSEN PHARMACEUTICA NV (BE) 2014-12-16 — — US disclosed
WO-2014149987-A1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 — — WO disclosed
US-20140275182-A1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 — — US disclosed
US-20140275182-A1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 — — US disclosed
WO-2014069963-A1 THIOARYL DERIVATIVES AS GPR120 AGONISTS LG LIFE SCIENCES LTD. (KR) 2014-05-08 — — WO disclosed
US-8309600-B2 GPR120 receptor agonists and uses thereof METABOLEX INC. (US) 2012-11-13 — — US disclosed
EP-2367793-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF Metabolex Inc. (US) 2011-09-28 — — EP disclosed
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. 2010-08-26 — — US disclosed
US-20100190831-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. 2010-07-29 — — US disclosed
WO-2010080537-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF METABOLEX, INC. (US) 2010-07-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150291527-A1 THIOARYL DERIVATIVES AS GPR120 AGONISTS GPR119, GLP1R, GCGR NR1H4 55/4885KMT2A 2598/4885MEN1 2442/4885
US-20100190831-A1 GPR120 RECEPTOR AGONISTS AND USES THEREOF GPR119, GPR52, GCGR NR1H4 118/4885KMT2A 2862/4885MEN1 4330/4885
US-20140275182-A1 BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120 GPR119, GPR180, GPR65 NR1H4 115/4885KMT2A 3652/4885MEN1 4778/4885
US-20100216827-A1 ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF GPR119, GPR52, GCGR NR1H4 59/4885KMT2A 2399/4885MEN1 4641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.