Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12003540 | 0.94 | HDAC3 (0.49) | HDAC1HDAC3HDAC2APPHDAC8 | |
| SCHEMBL17494710 | 0.83 | ALDH1A1 (0.47) | NPC1RAB9ATSHR | |
| SCHEMBL28647964 | 0.82 | NR1I2 (0.41) | HDAC1HDAC3HDAC2MMP2MMP12 | |
| SCHEMBL28408619 | 0.81 | CES1 (0.50) | MMP2MMP12 | |
| SCHEMBL24345107 | 0.81 | MMP2 (0.47) | MMP2MMP12 | |
| SCHEMBL31614581 | 0.81 | ESR1 (0.49) | MMP2MMP12NPC1RAB9ATSHR | |
| SCHEMBL31595927 | 0.81 | NR1I2 (0.42) | HDAC1HDAC3HDAC2MMP2MMP12 | |
| SCHEMBL25749243 | 0.81 | MMP2 (0.47) | MMP2MMP12 | |
| SCHEMBL9241002 | 0.80 | CES2 (0.49) | MMP2MMP12 | |
| SCHEMBL1315161 | 0.79 | MMP2 (0.52) | MMP2MMP12GSK3BRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691135-B2 | Synthesis of alkynones via carbonylative Sonogashira coupling reactions catalyzed by Pd(II)-N-Heterocyclic carbene-pyridine complexes | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2023-07-04 | — | — | US | disclosed |
| US-20220118435-A1 | SYNTHESIS OF ALKYNONES VIA CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS CATALYZED BY PD(II)-N-HETEROCYCLIC CARBENE-PYRIDINE COMPLEXES | KING FAHD UNIVERSITY OF PETROLEUM & MINERALS (SA) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691135-B2 | Synthesis of alkynones via carbonylative Sonogashira coupling reactions catalyzed by Pd(II)-N-Heterocyclic carbene-pyridine complexes | PDK2, SNCA, YAP1 | HDAC1 2261/4885HDAC3 2504/4885HDAC2 931/4885 |
| US-20220118435-A1 | SYNTHESIS OF ALKYNONES VIA CARBONYLATIVE SONOGASHIRA COUPLING REACTIONS CATALYZED BY PD(II)-N-HETEROCYCLIC CARBENE-PYRIDINE COMPLEXES | PDK2, SNCA, YAP1 | HDAC1 2261/4885HDAC3 2504/4885HDAC2 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.