Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28408619 | 0.81 | CES1 (0.50) | MMP2MMP12FFAR1FFAR4 | |
| SCHEMBL24345107 | 0.81 | MMP2 (0.47) | MMP2MMP12FFAR1FFAR4HSD17B3 | |
| SCHEMBL25749243 | 0.81 | MMP2 (0.47) | MMP2MMP12FFAR1FFAR4ALDH1A1 | |
| SCHEMBL9241002 | 0.80 | CES2 (0.49) | MMP2MMP12FFAR1FFAR4ALDH1A1 | |
| SCHEMBL24345232 | 0.79 | HDAC1 (0.47) | MMP2MMP12GSK3BTSHRRAB9A | |
| SCHEMBL9440264 | 0.78 | HSD17B3 (0.65) | MMP2MMP12MGLLGSK3BRAB9A | |
| SCHEMBL31614581 | 0.78 | ESR1 (0.49) | MMP2MMP12TSHRRAB9ACA1 | |
| SCHEMBL17602717 | 0.76 | VCP (0.47) | MMP2MMP12GSK3BRAB9AALDH1A1 | |
| SCHEMBL12348503 | 0.76 | FFAR1 (0.55) | MMP2MMP12MGLLTSHRHSD17B10 | |
| SCHEMBL24345826 | 0.75 | ALDH1A1 (0.50) | MGLLGSK3BTSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | MMP2 2261/4885MMP12 1275/4885MGLL 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.