Sugi Predict

Sugi Predict / Compounds / SCHEMBL24345841

SCHEMBL24345841

SCHEMBL24345841

CCc1cc(CCO)cs1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DAO P14920 2/20 0.46
▸ RAB9A P51151 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ USP2 O75604 1/20 0.35
▸ CYP4F2 P78329 1/20 0.34
▸ CYP4A11 Q02928 1/20 0.34
▸ LTB4R Q15722 4/20 0.34
▸ GAA P10253 4/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALOX5 P09917 1/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ CA2 P00918 1/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ APOBEC3G Q9HC16 1/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28407935 0.85 LTB4R (0.40) DAOLTB4RGAAALDH1A1MAPT
SCHEMBL5102754 0.83 — —
SCHEMBL8171670 0.83 DAO (0.44) DAORAB9ATP53USP2LTB4R
SCHEMBL830068 0.80 — —
SCHEMBL24346534 0.77 MEN1 (0.35) DAOUSP2CYP4F2CYP4A11LTB4R
SCHEMBL18067897 0.76 PTGS2 (0.46) DAOTP53LTB4RALDH1A1KDM4E
SCHEMBL1246833 0.76 LTB4R (0.37) DAORAB9ACYP4F2CYP4A11LTB4R
SCHEMBL5116069 0.75 LTB4R (0.37) DAORAB9ATP53LTB4RGAA
SCHEMBL1246005 0.75 LTB4R (0.44) DAOUSP2CYP4F2CYP4A11LTB4R
SCHEMBL15898838 0.75 LTB4R (0.32) LTB4RGAAALDH1A1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119343353-A 2-Methyl-4 ',5' -dihydrospiro [ piperidine-4, 7' -thieno [2,3-c ] pyran ] derivatives as APOL1 inhibitors and methods of use thereof 弗特克斯药品有限公司 2025-01-21 — — CN disclosed
CN-119013281-A 4',5' -Dihydrospiro [ piperidine-4, 7' -thieno [2,3-C ] pyran ] derivatives as APOL1 inhibitors and methods of use thereof 弗特克斯药品有限公司 2024-11-22 — — CN disclosed
WO-2023154344-A1 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 — — WO disclosed
WO-2023154309-A1 4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 — — WO disclosed
CN-116547287-A Inhibitors of APOL1 and methods of use thereof 弗特克斯药品有限公司 2023-08-04 — — CN disclosed
US-20220106327-A1 INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106327-A1 INHIBITORS OF APOL1 AND METHODS OF USING SAME APOL1, PNLIP, APOB DAO 806/4885RAB9A 3434/4885TP53 1706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.