Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24352318 | 0.80 | CASP6 (0.44) | ADRA2CADRA1ACD274BCHEACHE | |
| SCHEMBL23585490 | 0.78 | ADRA1A (0.44) | ADRA1ACYP2A6DPP4PTPRCCTSL | |
| SCHEMBL23330116 | 0.77 | TRPM8 (0.42) | ADRA2CADRA1ACD274BCHEACHE | |
| SCHEMBL23585267 | 0.76 | DPP4 (0.45) | ADRA1AKCNA5CYP2A6DPP4PTPRC | |
| SCHEMBL8550272 | 0.76 | ADRA2C (0.46) | ADRA2CHTR2AHTR2CHTR2BCD274 | |
| SCHEMBL607717 | 0.75 | ADRA2C (0.58) | ADRA2CBCHEACHEADRB2HTT | |
| Ethylene SCHEMBL27739074 | 0.74 | DPP4 (0.54) | ADRA1ACYP2A6DPP4PTPRCCTSL | |
| SCHEMBL4160810 | 0.73 | CYP2A6 (0.52) | ADRA1ACYP2A6PTPRCCTSLCTSS | |
| SCHEMBL14025128 | 0.73 | ADRA2C (0.46) | ADRA2CADRB2KDM4EADRB1ADRB3 | |
| SCHEMBL26239912 | 0.73 | ADRA2C (0.42) | ADRA2CADRA1AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119395-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119395-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | ADRA2C 197/4885ADRA1A 654/4885HTR2A 2912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.