Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 5/20 | 0.46 |
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | TEK | Q02763 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435966 | 0.92 | KDR (0.57) | KDRFLT1FLT4KCNH2MET | |
| SCHEMBL2435819 | 0.91 | KDR (0.53) | KDRFLT1FLT4LCKMET | |
| SCHEMBL2435957 | 0.86 | KDR (0.62) | KDRFLT1FLT4LCKMET | |
| SCHEMBL2434309 | 0.83 | KDR (0.50) | KDRFLT1FLT4KCNH2BRAF | |
| SCHEMBL2437252 | 0.81 | RAF1 (0.53) | KDRFLT1FLT4LCKMET | |
| SCHEMBL18615565 | 0.80 | KDR (0.47) | KDRLCKMETTEKBRAF | |
| SCHEMBL2706559 | 0.79 | KDR (0.46) | KDRLCKMETTEK | |
| SCHEMBL2434370 | 0.78 | KDR (0.59) | KDRFLT1FLT4KCNH2LCK | |
| SCHEMBL2435014 | 0.78 | KDR (0.52) | KDRFLT1FLT4LCKMET | |
| SCHEMBL2437406 | 0.78 | KDR (0.63) | KDRFLT1FLT4BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |