Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609814 | 0.90 | NAMPT (0.52) | NAMPTHDAC1SMN1; SMN2GSK3BDYRK1A | |
| Acetic Acid SCHEMBL28111547 | 0.89 | NAMPT (0.49) | NAMPTHDAC1SMN1; SMN2GRIN2BGSK3B | |
| SCHEMBL7324243 | 0.84 | NAMPT (0.46) | NAMPTHDAC1SMN1; SMN2GRIN2BGSK3B | |
| SCHEMBL24366049 | 0.82 | PTPN11 (0.65) | PTPN11NAMPTCYP17A1 | |
| SCHEMBL11728090 | 0.82 | RAB9A (0.52) | PTPN11SMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL24756649 | 0.82 | ALDH1A1 (0.51) | NAMPTHDAC1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL30136675 | 0.82 | ALDH1A1 (0.51) | NAMPTHDAC1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7081208 | 0.80 | NAMPT (0.46) | NAMPTHDAC1SMN1; SMN2MAPKAPK2RAB9A | |
| SCHEMBL3328875 | 0.80 | NAMPT (0.48) | NAMPTHDAC1SMN1; SMN2GRIN2BGSK3B | |
| SCHEMBL29651977 | 0.78 | HCAR3 (0.57) | HDAC1GRIN2BBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | PTPN11 1533/4885NAMPT 1439/4885HDAC1 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.