Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24397611 | 0.87 | CRBN (0.36) | CRBNTTR | |
| SCHEMBL24397609 | 0.86 | CRBN (0.38) | CRBNKEAP1NFE2L2EPHX2TTR | |
| SCHEMBL24397584 | 0.81 | ENO1 (0.36) | KEAP1NFE2L2EPHX2 | |
| SCHEMBL17282361 | 0.75 | CRBN (0.41) | CRBNTTR | |
| SCHEMBL18886281 | 0.75 | CRBN (0.41) | CRBNTTR | |
| SCHEMBL19164024 | 0.75 | CRBN (0.38) | CRBNTTR | |
| SCHEMBL18886307 | 0.74 | CRBN (0.38) | CRBNTTR | |
| SCHEMBL13695971 | 0.74 | CRBN (0.38) | CRBNTTR | |
| SCHEMBL14922169 | 0.74 | CRBN (0.38) | CRBNTTR | |
| SCHEMBL23234313 | 0.74 | CRBN (0.38) | CRBNTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295222-A1 | Conjugation Reagents and Methods Using 1,2-Cyclohexanediones | Encodia, Inc. (US) | 2023-09-21 | — | — | US | disclosed |
| US-11639366-B2 | Conjugation reagents and methods using 1,2-cyclohexanediones | Encodia, Inc. (US) | 2023-05-02 | — | — | US | disclosed |
| US-11639366-B2 | Conjugation reagents and methods using 1,2-cyclohexanediones | Encodia, Inc. (US) | 2023-05-02 | — | — | US | disclosed |
| US-20220144885-A1 | CONJUGATION REAGENTS AND METHODS USING 1,2-CYCLOHEXANEDIONES | Encodia, Inc. (US) | 2022-05-12 | — | — | US | disclosed |
| WO-2022094148-A1 | CONJUGATION REAGENTS AND METHODS USING 1,2-CYCLOHEXANEDIONES | Encodia, Inc. (US) | 2022-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144885-A1 | CONJUGATION REAGENTS AND METHODS USING 1,2-CYCLOHEXANEDIONES | TNNI3, CHD1, TNNT2 | CRBN 995/4885KEAP1 1967/4885NFE2L2 4206/4885 |
| US-20230295222-A1 | Conjugation Reagents and Methods Using 1,2-Cyclohexanediones | TNNI3, CHD1, TNNT2 | CRBN 995/4885KEAP1 1967/4885NFE2L2 4206/4885 |
| US-11639366-B2 | Conjugation reagents and methods using 1,2-cyclohexanediones | TNNI3, CHD1, TNNT2 | CRBN 995/4885KEAP1 1967/4885NFE2L2 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.