Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HAT1 | O14929 | 2/20 | 0.32 |
| ▸ | EP300 | Q09472 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344637 | 0.71 | TP53 (0.35) | ALDH1A1LMNA | |
| SCHEMBL19916781 | 0.70 | ALDH1A1 (0.46) | ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL16708773 | 0.67 | OPRM1 (0.41) | OPRM1OPRK1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL17383776 | 0.67 | ALDH1A1 (0.49) | OPRM1OPRK1ALDH1A1POLBNPC1 | |
| SCHEMBL7469718 | 0.66 | ALDH1A1 (0.40) | ALDH1A1GAASMN1; SMN2GABRA1GABRA5 | |
| SCHEMBL16373719 | 0.65 | ALDH1A1 (0.41) | ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL18724769 | 0.64 | ERN1 (0.36) | ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4509000 | 0.63 | — | — | |
| SCHEMBL17788527 | 0.63 | ALDH1A1 (0.38) | ALDH1A1GAAPOLBNPC1RAB9A | |
| SCHEMBL22789305 | 0.62 | SIGMAR1 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |