Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980302 | 0.74 | TSHR (0.37) | TP53HCAR3ALDH3A1ALDH1A3ALDH1A1 | |
| SCHEMBL24405524 | 0.73 | SIGMAR1 (0.36) | TP53ALDH1A1SIGMAR1LMNAMAPT | |
| SCHEMBL2090253 | 0.72 | C1R (0.37) | TP53ALDH1A1MAPT | |
| SCHEMBL2697490 | 0.72 | MAPT (0.33) | TP53ALDH1A1SIGMAR1LMNAMAPT | |
| SCHEMBL5421931 | 0.72 | TP53 (0.45) | TP53HCAR3ALDH1A1SIGMAR1ESR1 | |
| SCHEMBL21765851 | 0.71 | ALDH1A1 (0.35) | TP53ALDH1A1DRD3LMNAMAPT | |
| SCHEMBL19980344 | 0.71 | NPY2R (0.40) | — | |
| SCHEMBL24405809 | 0.71 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPT | |
| SCHEMBL24405832 | 0.71 | OPRM1 (0.39) | ALDH1A1LMNA | |
| SCHEMBL22738465 | 0.71 | DRD3 (0.37) | TP53HCAR3DRD3SIGMAR1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |