SCHEMBL244108

SCHEMBL244108

Ic1cc(-c2ccccc2)ncn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 1.00
ASIC3 Q9UHC3 2/20 0.59
KMO O15229 2/20 0.53
RAB9A P51151 3/20 0.52
NPC1 O15118 3/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
KMT2A Q03164 3/20 0.47
TSHR P16473 1/20 0.47
RECQL P46063 1/20 0.47
HRH4 Q9H3N8 1/20 0.45
TP53 P04637 1/20 0.42
MAPT P10636 1/20 0.42
MEN1 O00255 2/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CTDSP1 Q9GZU7 1/20 0.39
ADORA2A P29274 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL284286 0.84 ASIC3 (0.71) MIFASIC3KMORAB9ANPC1
SCHEMBL27904874 0.81 ASIC3 (0.68) MIFASIC3KMORAB9ANPC1
SCHEMBL29406194 0.81 ASIC3 (0.68) MIFASIC3KMORAB9ANPC1
SCHEMBL28218682 0.81 ASIC3 (0.68) MIFASIC3KMORAB9ANPC1
SCHEMBL20813389 0.81 MIF (0.68) MIFASIC3KMORAB9ANPC1
SCHEMBL18731738 0.79 ASIC3 (0.65) MIFASIC3KMORAB9ANPC1
SCHEMBL29730373 0.79 ASIC3 (0.65) MIFASIC3KMORAB9ANPC1
SCHEMBL17697185 0.79 ASIC3 (0.65) MIFASIC3KMORAB9ANPC1
SCHEMBL1445248 0.79 MIF (0.66) MIFASIC3KMORAB9ANPC1
SCHEMBL1445134 0.79 MIF (0.65) MIFKMOKMT2AMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250135196-A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS WITH INHIBITORS OF MIF, MICA, AND/OR MICB UNIV BROWN (US) 2025-05-01 US claimed
CN-114028399-A Application of MIF inhibitor 4-IPP in preparation of medicine for treating brain glioma 郑琳 2022-02-11 CN claimed
US-9155790-B2 Methods and compositions for modulating ocular damage University of Lousiville Research Foundation, Inc. (US) 2015-10-13 US claimed
US-8999984-B2 Macrophage migration inhibitory factor antagonists and methods of using same UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2015-04-07 US claimed
US-20130177552-A1 METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2013-07-11 US claimed
WO-2011146824-A1 METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2011-11-24 WO claimed
US-20110009412-A1 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2011-01-13 US claimed
CN-101528039-A Macrophage migration inhibitory factor antagonists and methods of using same UNIV LOUISVILLE RES FOUND (US) 2009-09-09 CN claimed
EP-2026654-A2 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2009-02-25 EP claimed
WO-2007140263-A9 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIV LOUISVILLE RES FOUND (US) 2008-04-03 WO claimed
WO-2007140263-A2 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2007-12-06 WO claimed
US-20260085468-A1 METHODS AND SYSTEMS FOR DYE REMOVAL FROM POLYMER TEXTILES ALLIANCE SUSTAINABLE ENERGY (US) 2026-03-26 US disclosed
US-12428417-B2 Inhibitors of macrophage migration inhibitory factor THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2025-09-30 US disclosed
EP-4615582-A1 MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) TARGETING FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER Board of Regents, The University of Texas System (US) 2025-09-17 EP disclosed
WO-2025097084-A1 BIOMARKER FOR FAMILIAL PLATELET DISORDER AND USES THEREOF OREGON HEALTH & SCIENCE UNIVERSITY (US) 2025-05-08 WO disclosed
CN-101528039-A Macrophage migration inhibitory factor antagonists and methods of using same UNIV LOUISVILLE RES FOUND (US) 2009-09-09 CN disclosed
EP-2026654-A2 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2009-02-25 EP disclosed
WO-2007140263-A9 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIV LOUISVILLE RES FOUND (US) 2008-04-03 WO disclosed
WO-2007140263-A9 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIV LOUISVILLE RES FOUND (US) 2008-04-03 WO disclosed
WO-2007140263-A2 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2007-12-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250135196-A1 COMPOSITIONS, SYSTEMS, AND METHODS FOR TREATING CANCER USING TUMOR TREATING FIELDS WITH INHIBITORS OF MIF, MICA, AND/OR MICB MIF, MICA, CD74 MIF 1/4885ASIC3 4275/4885KMO 4035/4885
US-20260085468-A1 METHODS AND SYSTEMS FOR DYE REMOVAL FROM POLYMER TEXTILES MPO, CES2, AOC3 MIF 4204/4885ASIC3 1070/4885KMO 771/4885
US-20110009412-A1 MACROPHAGE MIGRATION INHIBITORY FACTOR ANTAGONISTS AND METHODS OF USING SAME MIF, MMP12, CCL2 MIF 1/4885ASIC3 4508/4885KMO 3717/4885
US-20130177552-A1 METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE MIF, MMP1, CXCL12 MIF 1/4885ASIC3 4353/4885KMO 2308/4885
US-12428417-B2 Inhibitors of macrophage migration inhibitory factor MIF, CD209, F3 MIF 1/4885ASIC3 1951/4885KMO 4063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.