Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361328 | 0.78 | CA2 (0.48) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL24246848 | 0.71 | ALOX12 (0.40) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL11351266 | 0.71 | GABRA1 (0.50) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL26846725 | 0.69 | CA2 (0.37) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL18389205 | 0.68 | CA2 (0.39) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL20954046 | 0.66 | CA2 (0.44) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL20211348 | 0.66 | CA2 (0.44) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL242955 | 0.64 | CA2 (0.46) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL242956 | 0.64 | CA2 (0.46) | CA2ALOX12GABRA1GABRB2ALDH1A1 | |
| SCHEMBL961149 | 0.64 | CA2 (0.46) | CA2ALOX12GABRA1GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840517-B2 | Lappaconitine derivative with analgesic activity, and preparation and application thereof | SOUTHWEST JIAOTONG UNIVERSITY (CN) | 2023-12-12 | — | — | US | disclosed |
| US-20220144779-A1 | LAPPACONITINE DERIVATIVE WITH ANALGESIC ACTIVITY, AND PREPARATION AND APPLICATION THEREOF | SOUTHWEST JIAOTONG UNIVERSITY (CN) | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840517-B2 | Lappaconitine derivative with analgesic activity, and preparation and application thereof | LPXN, ACHE, OPRL1 | CA2 1256/4885ALOX12 1862/4885GABRA1 1331/4885 |
| US-20220144779-A1 | LAPPACONITINE DERIVATIVE WITH ANALGESIC ACTIVITY, AND PREPARATION AND APPLICATION THEREOF | LPXN, ACHE, OPRL1 | CA2 1256/4885ALOX12 1862/4885GABRA1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.