Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 4/20 | 0.33 |
| ▸ | FPR2 | P25090 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26205892 | 0.89 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ALMNAHSP90AA1 | |
| SCHEMBL24430116 | 0.86 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AHPGDHTT | |
| SCHEMBL24430113 | 0.85 | MEN1 (0.54) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL24430026 | 0.84 | KMT2A (0.52) | ALDH1A1MEN1KMT2ALMNAHSP90AA1 | |
| SCHEMBL24437357 | 0.84 | MEN1 (0.45) | ALDH1A1MEN1KMT2AKDM4EHSD17B3 | |
| SCHEMBL24437318 | 0.84 | RPS6KA3 (0.47) | ALDH1A1MEN1KMT2ALMNAPKM | |
| SCHEMBL24430074 | 0.82 | MEN1 (0.50) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL24430114 | 0.82 | MEN1 (0.68) | ALDH1A1MEN1KMT2ALMNAATM | |
| SCHEMBL24430013 | 0.82 | MEN1 (0.49) | ALDH1A1MEN1KMT2AHSP90AA1HPGD | |
| SCHEMBL24430078 | 0.81 | MEN1 (0.50) | ALDH1A1MEN1KMT2AKDM4EHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339860-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | SOUTHERN RES INST (US) | 2023-10-26 | — | — | US | disclosed |
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | Southern Reserach Institute (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | Southern Reserach Institute (US) | 2023-09-12 | — | — | US | disclosed |
| WO-2022109066-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE AND CHRONIC KIDNEY DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022109067-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE AND CHRONIC KIDNEY DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2022-05-27 | — | — | WO | disclosed |
| US-20220153702-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | UAB RESEARCH FOUNDATION | 2022-05-19 | — | — | US | disclosed |
| US-20220153695-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153695-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | HMOX1, GLS, HMOX2 | ALDH1A1 703/4885MEN1 4171/4885KMT2A 2088/4885 |
| US-20220153702-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | HMOX1, HMOX2, GLS | ALDH1A1 671/4885MEN1 4651/4885KMT2A 2904/4885 |
| US-20230339860-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | HMOX1, HMOX2, GLS | ALDH1A1 671/4885MEN1 4651/4885KMT2A 2904/4885 |
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | HMOX1, GLS, HMOX2 | ALDH1A1 703/4885MEN1 4171/4885KMT2A 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.