Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24430113 | 0.93 | MEN1 (0.54) | KMT2AMEN1RPS6KA3MGLLTDP1 | |
| SCHEMBL24430029 | 0.90 | MEN1 (0.54) | KMT2AMEN1RPS6KA3MGLLHSP90AA1 | |
| SCHEMBL24430074 | 0.90 | MEN1 (0.50) | KMT2AMEN1RPS6KA3MGLLPOLB | |
| SCHEMBL26205886 | 0.90 | KMT2A (0.50) | KMT2AMEN1RPS6KA3MGLLHSP90AA1 | |
| SCHEMBL24430114 | 0.90 | MEN1 (0.68) | KMT2AMEN1RPS6KA3MGLLALDH1A1 | |
| SCHEMBL24430013 | 0.89 | MEN1 (0.49) | KMT2AMEN1RPS6KA3MGLLHSP90AA1 | |
| SCHEMBL24430081 | 0.87 | MEN1 (0.48) | KMT2AMEN1RPS6KA3ALDH1A1KDM4E | |
| SCHEMBL24430002 | 0.87 | MEN1 (0.48) | KMT2AMEN1RPS6KA3MAPK1NPSR1 | |
| SCHEMBL24430022 | 0.87 | MEN1 (0.48) | KMT2AMEN1RPS6KA3MGLLHSP90AA1 | |
| SCHEMBL24430116 | 0.86 | ALDH1A1 (0.53) | KMT2AMEN1MGLLTDP1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339860-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | SOUTHERN RES INST (US) | 2023-10-26 | — | — | US | disclosed |
| US-20230339860-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | SOUTHERN RES INST (US) | 2023-10-26 | — | — | US | disclosed |
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | Southern Reserach Institute (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | Southern Reserach Institute (US) | 2023-09-12 | — | — | US | disclosed |
| WO-2022109067-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE AND CHRONIC KIDNEY DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2022109066-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE AND CHRONIC KIDNEY DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2022-05-27 | — | — | WO | disclosed |
| US-20220153702-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | UAB RESEARCH FOUNDATION | 2022-05-19 | — | — | US | disclosed |
| US-20220153695-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153695-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | HMOX1, GLS, HMOX2 | KMT2A 2088/4885MEN1 4171/4885RPS6KA3 1960/4885 |
| US-20220153702-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | HMOX1, HMOX2, GLS | KMT2A 2904/4885MEN1 4651/4885RPS6KA3 2231/4885 |
| US-20230339860-A1 | Compounds for the Treatment Of Acute and Chronic Kidney Disease | HMOX1, HMOX2, GLS | KMT2A 2904/4885MEN1 4651/4885RPS6KA3 2231/4885 |
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | HMOX1, GLS, HMOX2 | KMT2A 2088/4885MEN1 4171/4885RPS6KA3 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.