Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24437314 | 0.95 | KDM4C (0.40) | WNT1KDM4CBRD4CREBBPROCK2 | |
| SCHEMBL24437156 | 0.89 | CREBBP (0.40) | KDM4CBRD4CREBBPOPRM1OPRL1 | |
| SCHEMBL24437321 | 0.87 | GRM5 (0.40) | KDM4CBRD4CREBBPOPRM1OPRL1 | |
| SCHEMBL24437166 | 0.84 | OPRM1 (0.40) | KDM4CBRD4CREBBPOPRM1OPRL1 | |
| SCHEMBL24437151 | 0.79 | CNR1 (0.48) | KDM4CROCK2 | |
| SCHEMBL24437121 | 0.78 | CHRM1 (0.39) | WNT1KDM4CROCK2OPRM1OPRL1 | |
| SCHEMBL29601370 | 0.78 | ROCK2 (0.41) | WNT1KDM4CROCK2MAPK14HDAC1 | |
| SCHEMBL24437272 | 0.78 | ROCK2 (0.41) | WNT1KDM4CROCK2MAPK14HDAC1 | |
| SCHEMBL24437215 | 0.77 | KDM4C (0.41) | WNT1KDM4CROCK2MAPK14HDAC1 | |
| SCHEMBL24437158 | 0.77 | HTR3A (0.44) | WNT1KDM4CROCK2MAPK14HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459938-B2 | ORAI channel inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2025-11-04 | — | — | US | disclosed |
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12459938-B2 | ORAI channel inhibitors | ORAI1, CACNA1E, ORAI3 | WNT1 397/4885KDM4C 2563/4885BRD4 1522/4885 |
| US-20220153735-A1 | Orai Channel Inhibitors | ORAI2, ORAI1, ORAI3 | WNT1 2539/4885KDM4C 3959/4885BRD4 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.