SCHEMBL2443804

SCHEMBL2443804

O=C(OCc1ccccc1)c1[c]cccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 0.59
KMT2A Q03164 2/20 0.59
SLC6A2 P23975 1/20 0.59
SLC6A3 Q01959 1/20 0.59
ALDH1A1 P00352 7/20 0.54
LMNA P02545 3/20 0.54
MAPK1 P28482 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
TSHR P16473 2/20 0.49
MMP2 P08253 2/20 0.47
MMP9 P14780 2/20 0.47
MMP12 P39900 2/20 0.47
MAPT P10636 2/20 0.47
HPGD P15428 1/20 0.47
MMP1 P03956 1/20 0.47
CYP3A4 P08684 1/20 0.46
HCAR2 Q8TDS4 1/20 0.46
POLB P06746 1/20 0.45
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3716825 0.81 TDP1 (0.36) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL8625904 0.80 LMNA (0.49) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL129333 0.80 TSHR (0.55) KMT2AALDH1A1LMNAMAPK1TSHR
SCHEMBL11336915 0.80 TDP1 (0.35) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL8673620 0.79 TSHR (0.53) KMT2AALDH1A1LMNAMAPK1TSHR
SCHEMBL7625113 0.79 ALDH1A1 (0.43) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL130905 0.77 ALDH1A1 (0.58) TDP1KMT2ASLC6A2ALDH1A1LMNA
SCHEMBL11414429 0.77 KDM4E (0.50) KMT2AALDH1A1LMNAL3MBTL1MAPT
SCHEMBL9195782 0.77 TDP1 (0.54) TDP1KMT2ASLC6A2SLC6A3ALDH1A1
SCHEMBL9069406 0.77 RAB9A (0.54) KMT2AALDH1A1LMNATSHRMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013061105-A2 GLYCOGEN PHOSPHORYLASE INHIBITORS DEBRECENI EGYETEM (HU) 2013-05-02 WO claimed
CN-101218280-B Polymeric derivative of cytidine metabolic antagonist NIPPON KAYAKU KK 2012-06-27 CN claimed
CN-101218280-A Polymeric derivative of cytidine metabolic antagonist NIPPON KAYAKU KK (JP) 2008-07-09 CN claimed
CN-100349952-C Method for producing polycarbonate GEN ELECTRIC (US) 2007-11-21 CN claimed
EP-1799747-A1 METHOD FOR INCORPORATING ALKYL ESTER ENDGROUPS TO IMPROVE THE RELEASE PROPERTIES OF MELT POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2007-06-27 EP claimed
CN-1322025-C Method for end-capping polycarbonate resins and composition for use in same GEN ELECTRIC (US) 2007-06-20 CN claimed
EP-1436343-B8 METHOD FOR END-CAPPING POLYCARBONATE RESINS AND COMPOSITION FOR USE IN SAME GEN ELECTRIC (US) 2007-04-11 EP claimed
CN-1308370-C Method for end-capping polycarbonate resins and composition for use in same GEN ELECTRIC (US) 2007-04-04 CN claimed
US-7105626-B2 Method for incorporating alkyl ester endgroups to improve the release properties of melt polycarbonate GENERAL ELECTRIC COMPANY (US) 2006-09-12 US claimed
US-20060074216-A1 Method for incorporating alkyl ester endgroups to improve the release properties of melt polycarbonate SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2006-04-06 US claimed
WO-2003031497-A1 METHOD FOR END-CAPPING POLYCARBONATE RESINS AND COMPOSITION FOR USE IN SAME GENERAL ELECTRIC COMPANY (US) 2003-04-17 WO claimed
WO-2003022905-A1 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2003-03-20 WO claimed
US-6525163-B1 Reducing static charge, improving heat aging, and lowering water absorption by increasing endcap levels GENERAL ELECTRIC COMPANY 2003-02-25 US claimed
US-6500914-B1 MELT TRANSESTERIFICATION OF FREE HYDROXYL TERMINAL GROUPS WITH A DIARYL CARBONATE GENERAL ELECTRIC COMPANY 2002-12-31 US claimed
US-5998404-A NERVOUS SYSTEM DISORDERS ELI LILLY AND COMPANY (US) 1999-12-07 US claimed
EP-0452145-B1 Coated composition and its preparation process SHIONOGI & CO (JP) 1996-11-13 EP claimed
EP-0687249-A1 BALANOIDS ELI LILLY AND COMPANY (US) 1995-12-20 EP claimed
WO-1994020062-A2 BALANOIDS AS PROTEIN KINASE C INHIBITORS ELI LILLY AND COMPANY (US) 1994-09-15 WO claimed
EP-0078599-B1 COMPLEX COMPOUNDS BASED ON CYCLODEXTRINS TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) 1986-11-12 EP claimed
US-4214093-A PROTEOLYTIC ENZYME INHIBITORS TORII & CO., LTD. (JP) 1980-07-22 US claimed