Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.46 |
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | LCK | P06239 | 6/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372087 | 0.82 | MET (0.57) | METKDRSYKFGFR2 | |
| SCHEMBL20525605 | 0.72 | DRD2 (0.43) | MET | |
| SCHEMBL371832 | 0.71 | ACHE (0.60) | METKDRFGFR2 | |
| SCHEMBL2864532 | 0.70 | MET (0.63) | METKDRSYKFGFR2 | |
| SCHEMBL5824479 | 0.69 | SIGMAR1 (0.63) | METKDRLCKTEKFGFR2 | |
| SCHEMBL10701655 | 0.69 | ADRA1B (0.53) | — | |
| SCHEMBL2063576 | 0.69 | FGFR2 (0.64) | METKDRFGFR2 | |
| SCHEMBL2064072 | 0.68 | PDGFRA (0.58) | METKDRFGFR2 | |
| SCHEMBL17489704 | 0.68 | PDGFRA (0.65) | KDRFGFR2 | |
| SCHEMBL4141203 | 0.67 | FGFR2 (0.60) | KDRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |