SCHEMBL24445893

SCHEMBL24445893

COc1c(O)c(F)cc(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.39
MAPT P10636 2/20 0.38
CYP3A4 P08684 1/20 0.38
TUBB1 Q9H4B7 3/20 0.36
ALOX5 P09917 2/20 0.36
STAT3 P40763 2/20 0.36
NFE2L2 Q16236 2/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
HSD17B1 P14061 2/20 0.35
HSD17B2 P37059 2/20 0.35
ALDH1A1 P00352 2/20 0.34
PTGES O14684 1/20 0.34
PTGS1 P23219 1/20 0.34
KDM4E B2RXH2 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
APEX1 P27695 1/20 0.33
MPI P34949 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL448336 0.83 ALDH1A1 (0.39) TDP1MAPTCYP3A4TUBB1ALDH1A1
SCHEMBL24436698 0.82 TDP1 (0.39) TDP1MAPTCYP3A4TUBB1ALOX5
SCHEMBL24436687 0.82 TDP1 (0.39) TDP1MAPTCYP3A4TUBB1ALOX5
SCHEMBL9787541 0.78 ERN1 (0.48) MAPT
SCHEMBL2036050 0.77 TDP1 (0.44) TDP1MAPTCYP3A4TUBB1ALOX5
SCHEMBL4549699 0.77 TRPV4 (0.36) TDP1MAPTCYP3A4NFKB1ALDH1A1
SCHEMBL16256381 0.74 ACHE (0.36) TDP1MAPTCYP3A4TUBB1HSD17B1
SCHEMBL3537612 0.74 TUBB1 (0.34) TDP1MAPTCYP3A4TUBB1KMT2A
SCHEMBL6739577 0.73 TUBB1 (0.35) TDP1MAPTCYP3A4TUBB1ALDH1A1
SCHEMBL17431028 0.73 NFE2L2 (0.55) TDP1MAPTCYP3A4TUBB1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4001336-A1 POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE Shin-Etsu Chemical Co., Ltd. (JP) 2022-05-25 EP disclosed