Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458102 | 0.83 | GABRA1 (0.45) | GABRA1GABRB1SCN4ALMNAPDE2A | |
| SCHEMBL12407088 | 0.82 | GABRA1 (0.54) | GABRA1GABRB1SCN4ALMNAHTR2B | |
| SCHEMBL19832541 | 0.76 | GABRA1 (0.35) | GABRA1GABRB1SCN4APDE2A | |
| SCHEMBL19126691 | 0.75 | GABRA1 (0.39) | GABRA1GABRB1SCN4ALMNAPDE2A | |
| SCHEMBL11340181 | 0.75 | GABRA1 (0.70) | GABRA1GABRB1LMNAPDE2AHTR2B | |
| SCHEMBL24458096 | 0.74 | PDE2A (0.32) | PDE2AMEN1KMT2AKCNH2 | |
| SCHEMBL8975178 | 0.72 | TSHR (0.47) | SCN4AHTR2BTSHRALDH1A1RAPGEF4 | |
| SCHEMBL15541919 | 0.70 | GABRA1 (0.75) | GABRA1GABRB1LMNAHTR2BTSHR | |
| SCHEMBL2974180 | 0.70 | GABRA1 (0.56) | GABRA1GABRB1LMNAPDE2AHTR2B | |
| SCHEMBL19505672 | 0.69 | GABRA1 (0.61) | GABRA1GABRB1SCN4ALMNAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |