Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.46 |
| ▸ | SCN4A | P35499 | 4/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828947 | 0.84 | RAPGEF4 (0.46) | TSHRRAPGEF4SCN4ACES1CYP3A4 | |
| SCHEMBL13648047 | 0.80 | GAA (0.38) | TSHRRAPGEF4SCN4ACYP3A4ALDH1A1 | |
| SCHEMBL11229241 | 0.80 | CYP3A4 (0.52) | TSHRRAPGEF4SCN4ACYP3A4ALDH1A1 | |
| SCHEMBL10144171 | 0.80 | TSHR (0.35) | TSHRRAPGEF4SCN4ACES1CYP3A4 | |
| SCHEMBL12925873 | 0.80 | CES1 (0.36) | TSHRRAPGEF4SCN4ACES1CYP3A4 | |
| SCHEMBL7723814 | 0.80 | ALDH1A1 (0.44) | TSHRRAPGEF4SCN4ACYP3A4ALDH1A1 | |
| SCHEMBL765882 | 0.79 | CYP3A4 (0.58) | TSHRRAPGEF4SCN4ACES1CYP3A4 | |
| SCHEMBL11425977 | 0.76 | MAP3K14 (0.46) | SCN4ACYP3A4FFAR4GAA | |
| SCHEMBL14597274 | 0.76 | SCN4A (0.36) | TSHRRAPGEF4SCN4ACES1ALDH1A1 | |
| SCHEMBL13890679 | 0.76 | SCN4A (0.32) | TSHRRAPGEF4SCN4ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11845715-B2 | — | — | 2023-12-19 | — | — | US | disclosed |
| US-20230303495-A9 | PYRIDINE OXYNITRIDE, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI JEYOU PHARMACEUTICAL CO., LTD. (CN) | 2023-09-28 | — | — | US | disclosed |
| EP-3386500-B1 | BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS | UNIV ILLINOIS (US) | 2022-09-07 | — | — | EP | disclosed |
| US-20220194917-A1 | BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR COMPOUNDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2022-06-23 | — | — | US | disclosed |
| US-11345714-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| EP-3888749-A1 | SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME | The University of Queensland (AU) | 2021-10-06 | — | — | EP | disclosed |
| US-11072595-B2 | Benzothiophene-based selective estrogen receptor downregulator compounds | The Board of Trustees of lhe University of Illinois (US) | 2021-07-27 | — | — | US | disclosed |
| EP-3578547-B1 | SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME | UNIV QUEENSLAND (AU) | 2021-05-26 | — | — | EP | disclosed |
| US-20210139500-A1 | COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. (US) | 2021-05-13 | — | — | US | disclosed |
| WO-2021076890-A1 | INHIBITING HUMAN INTEGRIN α4β7 | MORPHIC THERAPEUTIC, INC. (US) | 2021-04-22 | — | — | WO | disclosed |
| US-20080188485-A1 | PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS | SCHERING CORPORATION | 2008-08-07 | — | — | US | disclosed |
| US-7384944-B2 | Piperazine derivatives useful as CCR5 antagonists | SCHERING CORPORATION (US) | 2008-06-10 | — | — | US | disclosed |
| US-7365078-B2 | Triaza-cyclopenta[cd]indene derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-04-29 | — | — | US | disclosed |
| US-7365078-B2 | Triaza-cyclopenta[cd]indene derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-04-29 | — | — | US | disclosed |
| WO-2007147701-A1 | AZOLINE COMPOUNDS FOR COMBATING ARTHROPOD PESTS | BASF SE (DE) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007071585-A1 | PESTCIDAL COMPOSITIONS | BASF SE (DE) | 2007-06-28 | — | — | WO | disclosed |
| EP-1787992-A1 | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2007-05-23 | — | — | EP | disclosed |
| US-20070060602-A1 | Triaza-cyclopenta [cd] indene derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-03-15 | — | — | US | disclosed |
| US-20070060602-A1 | Triaza-cyclopenta [cd] indene derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-03-15 | — | — | US | disclosed |
| EP-1704149-B1 | TRIAZA-CYCLOPENTA[CD]INDENE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2007-03-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188485-A1 | PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS | CCR5, CXCR3, CCR2 | TSHR 504/4885RAPGEF4 2633/4885SCN4A 1093/4885 |
| US-11845715-B2 | — | NLRP3, PYCARD, NOD1 | TSHR 4210/4885RAPGEF4 2478/4885SCN4A 1452/4885 |
| US-11345714-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | CKS1B, IKZF3, EPAS1 | TSHR 4025/4885RAPGEF4 2446/4885SCN4A 2002/4885 |
| US-20210139500-A1 | COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | CKS1B, IKZF3, CKS2 | TSHR 4026/4885RAPGEF4 2346/4885SCN4A 1711/4885 |
| US-20220194917-A1 | BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR COMPOUNDS | ESR1, ESR2, GPER1 | TSHR 287/4885RAPGEF4 2235/4885SCN4A 3751/4885 |
| US-20070060602-A1 | Triaza-cyclopenta [cd] indene derivatives | GIPR, HRH2, HRH1 | TSHR 167/4885RAPGEF4 963/4885SCN4A 3344/4885 |
| US-20230303495-A9 | PYRIDINE OXYNITRIDE, PREPARATION METHOD THEREFOR AND USE THEREOF | SCN11A, HCN4, CACNA1F | TSHR 3349/4885RAPGEF4 758/4885SCN4A 31/4885 |
| US-11072595-B2 | Benzothiophene-based selective estrogen receptor downregulator compounds | ESR1, ESR2, GPER1 | TSHR 287/4885RAPGEF4 2235/4885SCN4A 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.