Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458099 | 0.83 | CES2 (0.34) | PDE2APTGS1PTGS2CES2CES1 | |
| SCHEMBL25109665 | 0.83 | TRPM8 (0.40) | PDE2ACES2CES1METAP2KCNH2 | |
| SCHEMBL9945897 | 0.82 | LMNA (0.33) | — | |
| SCHEMBL19682788 | 0.78 | — | — | |
| SCHEMBL1748548 | 0.76 | ALDH1A1 (0.34) | — | |
| SCHEMBL23495805 | 0.75 | MEN1 (0.40) | PTGS1PTGS2CES2CES1MEN1 | |
| SCHEMBL13265101 | 0.74 | MEN1 (0.41) | PDE2ACES2CES1METAP2KCNH2 | |
| SCHEMBL16629395 | 0.74 | MEN1 (0.41) | PDE2APTGS1PTGS2CES2CES1 | |
| SCHEMBL17215607 | 0.74 | MEN1 (0.41) | PDE2ACES2CES1METAP2KCNH2 | |
| SCHEMBL24458097 | 0.74 | GABRA1 (0.45) | PDE2AKCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |