Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 2/20 | 0.78 |
| ▸ | SERPINA6 | P08185 | 5/20 | 0.81 |
| ▸ | SHBG | P04278 | 4/20 | 0.81 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.81 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 13/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.78 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | PGR | P06401 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.64 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aldosterone SCHEMBL21950215 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL19327156 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL1675 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL7191919 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL14373307 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL600774 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL15935548 | 0.90 | NR3C2 (1.00) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Hydrocortisone SCHEMBL5328946 | 0.90 | HIF1A (0.82) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL21267959 | 0.89 | NR3C2 (0.98) | SERPINA6SHBGNR3C2PRKAA2HIF1A | |
| Aldosterone SCHEMBL21082811 | 0.89 | NR3C2 (0.98) | SERPINA6SHBGNR3C2PRKAA2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115184525-A | Method for simultaneously detecting compounds with large difference in neutral properties in same sample | 裕菁科技(上海)有限公司 | 2022-10-14 | — | — | CN | disclosed |
| EP-2583208-A2 | APPARATUS, METHOD AND COMPUTER-READABLE STORAGE MEDIUM FOR EVALUATING A PHYSIOLOGICAL CONDITION OF A PATIENT | Jumplion, Inc. (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011159996-A2 | APPARATUS, METHOD AND COMPUTER-READABLE STORAGE MEDIUM FOR EVALUATING A PHYSIOLOGICAL CONDITION OF A PATIENT | JUMPLION, INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| EP-1644743-A1 | THYROID HORMONE ANALYSIS BY MASS SPECTROMETRY | GEORGETOWN UNIVERSITY (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004090553-A1 | THYROID HORMONE ANALYSIS BY MASS SPECTROMETRY | GEORGETOWN UNIVERSITY (US) | 2004-10-21 | — | — | WO | disclosed |