Aldosterone

Aldosterone

SCHEMBL600774

C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)CO)[C@@]3(C=O)CC(O)[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 7/20 1.00
SHBG P04278 4/20 1.00
SERPINA6 P08185 4/20 1.00
PRKAA2 P54646 1/20 1.00
SMN1; SMN2 Q16637 6/20 0.77
HIF1A Q16665 6/20 0.77
LMNA P02545 4/20 0.77
HSD17B10 Q99714 4/20 0.77
MAPT P10636 3/20 0.77
CYP3A4 P08684 3/20 0.77
NFKB1 P19838 2/20 0.77
MAPK1 P28482 2/20 0.77
BLM P54132 1/20 0.77
CYP2C9 P11712 1/20 0.77
TSHR P16473 1/20 0.77
SLC22A2 O15244 1/20 0.77
SLC22A1 O15245 1/20 0.77
SLC22A3 O75751 1/20 0.77
THPO P40225 1/20 0.77
MTOR P42345 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aldosterone SCHEMBL15935548 1.00 NR3C2 (1.00) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL19327156 1.00 NR3C2 (1.00) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL7191919 1.00 NR3C2 (1.00) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL21950215 1.00 NR3C2 (1.00) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL1675 1.00 NR3C2 (1.00) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL14373307 1.00 NR3C2 (1.00) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL21267959 0.99 NR3C2 (0.98) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL21082811 0.99 NR3C2 (0.98) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL27949081 0.99 NR3C2 (0.98) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2
Aldosterone SCHEMBL7992710 0.97 NR3C2 (0.94) NR3C2SHBGSERPINA6PRKAA2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12280021-B2 Affinity medicant conjugate AF CHEMICALS, LLC (US) 2025-04-22 US claimed
US-20250296912-A1 AFFINITY ILLUDOFULVENE CONJUGATES Illudent, Inc. (US) 2025-09-25 US disclosed
US-20250241872-A1 AFFINITY MEDICANT CONJUGATE Illudent, Inc. (US) 2025-07-31 US disclosed
US-12280021-B2 Affinity medicant conjugate AF CHEMICALS, LLC (US) 2025-04-22 US disclosed
US-12269793-B2 Affinity illudofulvene conjugates AF CHEMICALS, LLC (US) 2025-04-08 US disclosed
EP-4257186-B1 AFFINITY MEDICANT CONJUGATES AF CHEMICALS LLC (US) 2024-12-04 EP disclosed
US-20230372267-A1 AFFINITY MEDICANT CONJUGATE Califia Pharma Inc. (US) 2023-11-23 US disclosed
EP-4257186-A2 AFFINITY MEDICANT CONJUGATES AF Chemicals LLC (US) 2023-10-11 EP disclosed
US-20230263829-A1 ENABLING CHOLESTEROL CATABOLISM IN HUMAN CELLS University of South Alabama Foundation for Research and Commercialization 2023-08-24 US disclosed
EP-3129357-B1 AFFINITY MEDICANT CONJUGATES AF CHEMICALS LLC (US) 2023-08-23 EP disclosed
US-20040138187-A1 Therapeutic treatment methods BIOVIE INC. 2004-07-15 US disclosed
WO-2004019953-A1 THERAPEUTIC TREATMENT METHODS HOLLIS-EDEN PHARMACEUTICALS, INC. (US) 2004-03-11 WO disclosed
EP-1372664-A1 USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES Hollis-Eden Pharmaceuticals Inc. (US) 2004-01-02 EP disclosed
US-20030083231-A1 Blood cell deficiency treatment method BIOVIE INC. 2003-05-01 US disclosed
WO-2002069977-A1 USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES HOLLIS-EDEN PHARMACEUTICALS, INC. (US) 2002-09-12 WO disclosed
US-6274118-B1 INJECTING PATIENT HAVING ENDOCRINE CANCER IN NON-PROSTATIC TISSUE WITH BIOLOGICAL BINDING UNITS WHICH BIND TO PROSTATE SPECIFIC ANTIGEN PRODUCED BY NON-PROSTATIC TISSUE NORDION INTERNATIONAL INC. (CA) 2001-08-14 US disclosed
US-6197833-B1 Neuroprotective effects of polycyclic phenolic compounds APOLLO BIOPHARMACEUTICS, INC. 2001-03-06 US disclosed
US-5859001-A Neuroprotective effects of polycyclic phenolic compounds UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 1999-01-12 US disclosed
EP-0565674-B1 METHOD FOR MEMORY ENHANCEMENT AND QUALITY OF LIFE IMPROVEMENT HOPE CITY (US) 1999-01-07 EP disclosed
WO-1995002424-A1 LOCALIZATION AND THERAPY OF NON-PROSTATIC ENDOCRINE CANCER WITH AGENTS DIRECTED AGAINST PROSTATE SPECIFIC ANTIGEN NORDION INTERNATIONAL INC. (CA) 1995-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250296912-A1 AFFINITY ILLUDOFULVENE CONJUGATES OGFR, TNFSF11, FCER2 NR3C2 3284/4885SHBG 366/4885SERPINA6 299/4885
US-12280021-B2 Affinity medicant conjugate FCER2, HDGF, FCGR2A NR3C2 606/4885SHBG 27/4885SERPINA6 79/4885
US-20030083231-A1 Blood cell deficiency treatment method THPO, HPGDS, MPL NR3C2 54/4885SHBG 26/4885SERPINA6 362/4885
US-20230372267-A1 AFFINITY MEDICANT CONJUGATE FCER2, HDGF, FCGR2A NR3C2 606/4885SHBG 27/4885SERPINA6 79/4885
US-12269793-B2 Affinity illudofulvene conjugates OGFR, TNFSF11, FCER2 NR3C2 3284/4885SHBG 366/4885SERPINA6 299/4885
US-20040138187-A1 Therapeutic treatment methods ELANE, ALOX15, IL15 NR3C2 30/4885SHBG 93/4885SERPINA6 119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.