Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16908173 | 0.81 | MMP2 (0.49) | GRIA1ITGB3ITGA2BHDAC2HDAC8 | |
| SCHEMBL24114487 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9AHDAC2HDAC8HDAC6 | |
| SCHEMBL18759290 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9AHDAC2HDAC8HDAC6 | |
| SCHEMBL24114462 | 0.81 | PSMB5 (0.46) | SMN1; SMN2GRIA1ITGB3ITGA2BMEN1 | |
| SCHEMBL18759285 | 0.81 | PSMB5 (0.46) | SMN1; SMN2GRIA1ITGB3ITGA2BMEN1 | |
| SCHEMBL18759659 | 0.80 | CTSS (0.45) | SMN1; SMN2 | |
| SCHEMBL24114400 | 0.74 | CTSS (0.51) | GRIA1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL31174580 | 0.73 | SMN1; SMN2 (0.68) | SMN1; SMN2ITGB3ITGA2BHDAC2HDAC8 | |
| SCHEMBL24130642 | 0.73 | ITGB3 (0.50) | ITGB3ITGA2BRAB9AHDAC2HDAC8 | |
| SCHEMBL24130644 | 0.73 | ITGB3 (0.50) | ITGB3ITGA2BRAB9AHDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006012-A1 | PROTEASOME INHIBITORS AND USES THEREOF | Cornell University (US) | 2022-06-01 | — | — | EP | disclosed |