Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 15/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508825 | 0.95 | CPB2 (0.38) | CPB2KDM4EALDH1A1PKM | |
| SCHEMBL510352 | 0.86 | GPR119 (0.34) | KDM4EALDH1A1PKMTDP1HSD17B10 | |
| SCHEMBL20634895 | 0.75 | ALDH1A1 (0.36) | KDM4EALDH1A1PKMTDP1 | |
| SCHEMBL27907268 | 0.71 | CA12 (0.37) | CPB2 | |
| SCHEMBL29485984 | 0.70 | HDAC6 (0.36) | CPB2 | |
| SCHEMBL19466128 | 0.70 | CA14 (0.39) | CPB2ALDH1A1TDP1HSD17B10 | |
| SCHEMBL30674370 | 0.69 | SIGMAR1 (0.44) | KDM4EALDH1A1PKMTDP1HSD17B10 | |
| SCHEMBL16789557 | 0.68 | HDAC1 (0.38) | ALDH1A1TDP1HSD17B10 | |
| SCHEMBL8321919 | 0.68 | CA14 (0.38) | ALDH1A1 | |
| SCHEMBL29485907 | 0.68 | CA14 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137143-B1 | PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES | NABRIVA THERAPEUTICS AG (AT) | 2011-09-07 | — | — | EP | disclosed |