SCHEMBL510352

SCHEMBL510352

CN(CCCC1CC=CCC1)C(=O)OC(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 4/20 0.34
KDM4E B2RXH2 4/20 0.34
ALDH1A1 P00352 3/20 0.34
PKM P14618 1/20 0.34
FPR3 P25089 1/20 0.31
FPR2 P25090 1/20 0.31
TDP1 Q9NUW8 4/20 0.31
METAP2 P50579 1/20 0.31
HTR2C P28335 2/20 0.31
SLC6A4 P31645 2/20 0.31
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL508825 0.88 CPB2 (0.38) KDM4EALDH1A1PKM
SCHEMBL2447140 0.86 CPB2 (0.35) KDM4EALDH1A1PKMTDP1HSD17B10
SCHEMBL27123113 0.78 ITGB3 (0.37) GPR119
SCHEMBL13650556 0.77 ALDH1A1 (0.37) GPR119ALDH1A1FPR3FPR2TDP1
SCHEMBL20634895 0.76 ALDH1A1 (0.36) KDM4EALDH1A1PKMTDP1
SCHEMBL28868811 0.75 GPR119 (0.44) GPR119KDM4EPKM
SCHEMBL6018866 0.73 LSS (0.35) GPR119FPR3FPR2TDP1METAP2
SCHEMBL6018862 0.73 LSS (0.35) GPR119FPR3FPR2TDP1METAP2
SCHEMBL30674370 0.73 SIGMAR1 (0.44) KDM4EALDH1A1PKMTDP1HSD17B10
SCHEMBL509729 0.73 GPR119 (0.36) GPR119PKMFPR3FPR2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220218713-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2022-07-14 US disclosed
US-20210113571-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2021-04-22 US disclosed
US-20200281933-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2020-09-10 US disclosed
US-20200030335-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2020-01-30 US disclosed
US-20190175603-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2019-06-13 US disclosed
US-20180303842-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2018-10-25 US disclosed
US-20170266194-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2017-09-21 US disclosed
EP-2380874-B1 Pleuromutilin derivatives for the treatment of diseases mediated by microbes NABRIVA THERAPEUTICS AG (AT) 2016-12-28 EP disclosed
US-20140256731-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2014-09-11 US disclosed
US-20130040954-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HONG KONG KING-FRIEND INDUSTRIAL COMPANY LTD. (CN) 2013-02-14 US disclosed
US-8153689-B2 Pleuromutilin derivatives for the treatment of diseases mediated by microbes NABRIVA THERAPEUTICS AG (AT) 2012-04-10 US disclosed
US-20120029072-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG 2012-02-02 US disclosed
US-8071643-B2 Pleuromutilin derivatives for the treatment of diseases mediated by microbes NABRIVA THERAPEUTICS AG (AT) 2011-12-06 US disclosed
EP-2380874-A2 Pleuromutilin derivatives for the treatment of diseases mediated by microbes Nabriva Therapeutics AG (AT) 2011-10-26 EP disclosed
EP-2137143-B1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2011-09-07 EP disclosed
US-20100035987-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2010-02-11 US disclosed
EP-2137143-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES Nabriva Therapeutics AG (AT) 2009-12-30 EP disclosed
WO-2008113089-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES NABRIVA THERAPEUTICS AG (AT) 2008-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200281933-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 335/4885KDM4E 4814/4885ALDH1A1 870/4885
US-20140256731-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 401/4885KDM4E 4787/4885ALDH1A1 1061/4885
US-20220218713-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 383/4885KDM4E 4793/4885ALDH1A1 852/4885
US-20130040954-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 401/4885KDM4E 4787/4885ALDH1A1 1061/4885
US-20190175603-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 335/4885KDM4E 4814/4885ALDH1A1 870/4885
US-20170266194-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HRH4, HRH2, CHRM1 GPR119 673/4885KDM4E 4123/4885ALDH1A1 1122/4885
US-20100035987-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, FABP6, ALPI GPR119 260/4885KDM4E 4799/4885ALDH1A1 1565/4885
US-20200030335-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES HRH4, HRH2, CHRM1 GPR119 673/4885KDM4E 4123/4885ALDH1A1 1122/4885
US-20210113571-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 383/4885KDM4E 4793/4885ALDH1A1 852/4885
US-20180303842-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, PLEC, FABP6 GPR119 335/4885KDM4E 4814/4885ALDH1A1 870/4885
US-20120029072-A1 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES FABP2, FABP6, PLEC GPR119 242/4885KDM4E 4755/4885ALDH1A1 654/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.