Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477482 | 0.90 | PDPK1 (0.54) | ALDH1A1KDM4EHPGDADORA3ADORA2A | |
| SCHEMBL24477300 | 0.87 | ALDH1A1 (0.72) | ALDH1A1KDM4EHPGDADORA3ADORA2A | |
| SCHEMBL24477484 | 0.80 | KDM4E (0.49) | ALDH1A1KDM4EHPGDADORA3ADORA2A | |
| SCHEMBL22472774 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDADORA3ADORA2A | |
| SCHEMBL24477299 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDADORA3ADORA2A | |
| SCHEMBL24477483 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDMEN1POLB | |
| SCHEMBL22767220 | 0.73 | HSD11B1 (0.42) | ALDH1A1KDM4EHPGDMEN1POLB | |
| SCHEMBL22472783 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDADORA3ADORA2A | |
| SCHEMBL24477486 | 0.71 | GSK3A (0.48) | ALDH1A1KDM4EHPGDPOLBCASP1 | |
| SCHEMBL22767520 | 0.70 | HSD11B1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | PARK7, PNP, GAA | ALDH1A1 1213/4885KDM4E 899/4885HPGD 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.