Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.54 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477485 | 0.90 | ALDH1A1 (0.52) | PDPK1PRKCZMARK2ADORA3ADORA2A | |
| SCHEMBL24477299 | 0.86 | ALDH1A1 (0.71) | ADORA3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL24477290 | 0.79 | ADORA3 (0.50) | ADORA3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL22472767 | 0.79 | ADORA2A (0.43) | ADORA3ADORA2AADORA1ALDH1A1MAPT | |
| SCHEMBL24477300 | 0.77 | ALDH1A1 (0.72) | ADORA3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL24477486 | 0.74 | GSK3A (0.48) | PDPK1PRKCZMARK2KDM4EALDH1A1 | |
| SCHEMBL22767520 | 0.72 | HSD11B1 (0.44) | PDPK1PRKCZMARK2KDM4EALDH1A1 | |
| SCHEMBL17739834 | 0.71 | GBA1 (0.63) | KDM4EALDH1A1HPGDCYP1A1HSD17B10 | |
| SCHEMBL24477293 | 0.71 | APOBEC3A (0.50) | ADORA3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL22472753 | 0.71 | APOBEC3A (0.46) | ADORA3ADORA2AADORA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169652-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | PARK7, PNP, GAA | PDPK1 160/4885PRKCZ 2235/4885MARK2 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.