Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451851 | 0.88 | PTGS1 (0.40) | PTGS1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL2777410 | 0.88 | PTGS1 (0.40) | PTGS1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL10000944 | 0.80 | MAPT (0.53) | PTGS1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL2449797 | 0.79 | AR (0.42) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2448045 | 0.79 | KIF11 (0.50) | ALDH1A1MAPTKDM4EPOLBCYP2C9 | |
| SCHEMBL123764 | 0.78 | PTGS1 (0.58) | PTGS1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL11063307 | 0.78 | PTGS1 (0.56) | PTGS1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL30345552 | 0.78 | PTGS1 (0.56) | PTGS1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL2488367 | 0.77 | RAB9A (0.56) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL8968762 | 0.76 | KIF11 (0.50) | ALDH1A1SMN1; SMN2MAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | disclosed |