Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452091 | 0.88 | RAB9A (0.43) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2455599 | 0.85 | RAB9A (0.51) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2451911 | 0.85 | RAB9A (0.51) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2457235 | 0.83 | NPC1 (0.42) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2449570 | 0.83 | MAPT (0.45) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2452036 | 0.81 | RAB9A (0.36) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2449524 | 0.81 | SOS1 (0.44) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2452741 | 0.80 | NPC1 (0.36) | RAB9ANPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2449797 | 0.79 | AR (0.42) | MAPTALDH1A1POLBGAACYP1A2 | |
| SCHEMBL2448045 | 0.79 | KIF11 (0.50) | MAPTALDH1A1KDM4EPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | disclosed |