Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.42 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451540 | 0.89 | KIF11 (0.46) | KIF11L3MBTL1MAPTNPSR1LTA4H | |
| SCHEMBL2778490 | 0.89 | KIF11 (0.46) | KIF11L3MBTL1MAPTNPSR1LTA4H | |
| SCHEMBL2452091 | 0.87 | RAB9A (0.43) | L3MBTL1MAPTLTA4HALDH1A1KDM4E | |
| SCHEMBL2487238 | 0.83 | KIF11 (0.46) | KIF11L3MBTL1MAPTNPSR1LTA4H | |
| SCHEMBL2449797 | 0.82 | AR (0.42) | L3MBTL1MAPTF10ALDH1A1TTBK1 | |
| SCHEMBL12731717 | 0.81 | LTA4H (0.51) | KIF11L3MBTL1MAPTNPSR1LTA4H | |
| SCHEMBL27579381 | 0.80 | LTA4H (0.59) | KIF11L3MBTL1MAPTNPSR1LTA4H | |
| SCHEMBL9798371 | 0.80 | LTA4H (0.54) | KIF11L3MBTL1MAPTNPSR1LTA4H | |
| SCHEMBL2448201 | 0.79 | PTGS1 (0.39) | MAPTALDH1A1KDM4ECYP2C9POLB | |
| SCHEMBL2488367 | 0.79 | RAB9A (0.56) | MAPTNPSR1ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | claimed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | claimed |