Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.37 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454096 | 0.87 | MAOB (0.41) | ARSCN5ASCN9AMAPTABL1 | |
| SCHEMBL2777104 | 0.87 | MAOB (0.41) | ARSCN5ASCN9AMAPTABL1 | |
| SCHEMBL2448045 | 0.82 | KIF11 (0.50) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2448201 | 0.79 | PTGS1 (0.39) | MAPTHTTTP53CYP2C9MEN1 | |
| SCHEMBL19628791 | 0.79 | MAPT (0.52) | ARSCN5ASCN9AMAPTCYP2C9 | |
| SCHEMBL2488367 | 0.79 | RAB9A (0.56) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2449524 | 0.78 | SOS1 (0.44) | MAPTMAOBSLC6A4HTR2AMAP4K4 | |
| SCHEMBL2452091 | 0.78 | RAB9A (0.43) | SCN5ASCN9AMAPTLMNASLC6A4 | |
| SCHEMBL2449570 | 0.76 | MAPT (0.45) | MAPTLMNAHTTSLC6A4HTR2A | |
| SCHEMBL11664698 | 0.76 | AR (0.57) | ARSCN5ASCN9ASLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364088-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | Biogen Idec MA Inc. (US) | 2011-09-14 | — | — | EP | claimed |
| WO-2010051030-A1 | BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS | BIOGEN IDEC MA INC. (US) | 2010-05-06 | — | — | WO | claimed |