Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13403398 | 0.81 | CYP1A2 (0.52) | PRKDCALDH1A1CA2TSHRPTGS2 | |
| SCHEMBL724406 | 0.81 | PTGS2 (0.59) | CA2PTGS2CYP3A4MAPTTUBB1 | |
| SCHEMBL4054977 | 0.79 | MAPT (0.51) | ERN1CA2KDM4EPTGS2CYP3A4 | |
| SCHEMBL30041126 | 0.78 | CA2 (0.43) | ALDH1A1PPARGPPARDPPARACA2 | |
| SCHEMBL14280291 | 0.76 | ALDH1A1 (0.38) | ALDH1A1PPARGPPARDPPARACA2 | |
| SCHEMBL15150156 | 0.76 | MEN1 (0.40) | ALDH1A1PPARGPPARDPPARACA2 | |
| SCHEMBL8429647 | 0.76 | PTGS2 (0.64) | ALDH1A1PPARGPPARDPPARACA2 | |
| SCHEMBL30644304 | 0.75 | ALDH1A1 (0.69) | ALDH1A1PPARGPPARDPPARACA2 | |
| SCHEMBL557409 | 0.75 | ALDH1A1 (0.69) | ALDH1A1PPARGPPARDPPARACA2 | |
| SCHEMBL13403394 | 0.75 | MAPT (0.51) | ALDH1A1PPARGPPARDPPARAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544679-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112828-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |