Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | BCL3 | P20749 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611567 | 0.89 | MAPK14 (0.44) | MAPK14TSHRKMT2AALDH1A1MAPK10 | |
| SCHEMBL2448328 | 0.88 | MAPK14 (0.61) | MAPK14MCHR1PKM | |
| SCHEMBL2445182 | 0.84 | MAPK14 (0.73) | MAPK14KMT2AMCHR1ALDH1A1KDM4E | |
| SCHEMBL5296558 | 0.84 | MAPK14 (0.62) | MAPK14KMT2AMCHR1ALDH1A1KDM4E | |
| SCHEMBL2445975 | 0.83 | MAPK14 (0.49) | MAPK14TSHRKMT2AALDH1A1KDM4E | |
| SCHEMBL2443328 | 0.82 | MAPK14 (0.81) | MAPK14MCHR1ALDH1A1 | |
| SCHEMBL31371552 | 0.82 | MAPK14 (0.81) | MAPK14MCHR1ALDH1A1 | |
| SCHEMBL2443317 | 0.80 | MAPK14 (0.63) | MAPK14LMNATSHRKMT2AMCHR1 | |
| SCHEMBL2446092 | 0.79 | MAPK14 (0.56) | MAPK14LMNATSHRMCHR1IRAK4 | |
| SCHEMBL2450576 | 0.79 | MAPK14 (0.59) | MAPK14LMNAMCHR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017641-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-13 | — | — | US | disclosed |