Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24512696 | 0.75 | ALDH1A1 (0.46) | L3MBTL1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL1415792 | 0.75 | L3MBTL1 (0.63) | L3MBTL1MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6943230 | 0.73 | MEN1 (0.63) | L3MBTL1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL10708134 | 0.72 | L3MBTL1 (0.50) | L3MBTL1MAPTALDH1A1KDM4EMAPK14 | |
| SCHEMBL31129055 | 0.72 | POLB (0.40) | L3MBTL1ALDH1A1KDM4ELMNAMAPK14 | |
| SCHEMBL4976296 | 0.72 | ALDH1A1 (0.39) | MAPTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL16838775 | 0.71 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL21901753 | 0.71 | ALDH1A1 (0.66) | L3MBTL1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL20524290 | 0.70 | MEN1 (0.58) | L3MBTL1MAPTALDH1A1KDM4ESCN9A | |
| SCHEMBL24512733 | 0.70 | MAPT (0.47) | L3MBTL1MAPTSMN1; SMN2RAB9ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | L3MBTL1 3807/4885MAPT 4781/4885ALDH1A1 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.