Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRZ1 | P23471 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940828 | 0.89 | LMNA (0.47) | PTPRZ1STSALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11507063 | 0.87 | PTPRZ1 (0.61) | PTPRZ1PTPN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8941529 | 0.82 | PTPRZ1 (0.56) | PTPRZ1PTPN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6854376 | 0.80 | STS (0.52) | PARP10PARP3STSALDH1A1SMN1; SMN2 | |
| SCHEMBL8941641 | 0.79 | PTPRZ1 (0.50) | PTPRZ1PTPN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11060588 | 0.79 | PTPRZ1 (0.53) | PTPRZ1PARP10PTPN1ALDH1A1LMNA | |
| SCHEMBL8941500 | 0.77 | PTPRZ1 (0.51) | PTPRZ1PTPN1ALDH1A1SMN1; SMN2EPAS1 | |
| SCHEMBL8941541 | 0.77 | PTPRZ1 (0.51) | PTPRZ1PTPN1ALDH1A1SMN1; SMN2EPAS1 | |
| SCHEMBL5050902 | 0.77 | PARP10 (0.65) | PARP10PARP3STSALDH1A1SMN1; SMN2 | |
| SCHEMBL1663469 | 0.77 | PARP10 (0.65) | PARP10PARP3STSALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | PTPRZ1 458/4885PARP10 356/4885PARP3 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.