Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 8/20 | 0.36 |
| ▸ | PFKFB4 | Q16877 | 4/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22479061 | 0.82 | NPC1 (0.37) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL20114351 | 0.81 | PFKFB3 (0.43) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL13522721 | 0.78 | NPC1 (0.44) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL17339892 | 0.77 | IDO1 (0.45) | RAB9APIM1PIM2PARP15PARP10 | |
| SCHEMBL13772192 | 0.74 | LMNA (0.39) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL1102421 | 0.70 | GPR3 (0.54) | NPC1SCN4ARAB9ASMN1; SMN2PFKFB3 | |
| SCHEMBL24513019 | 0.70 | APP (0.40) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL20079931 | 0.70 | PFKFB3 (0.34) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL22675062 | 0.70 | PIM1 (0.40) | LMNANPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL11714081 | 0.69 | RAB9A (0.45) | LMNANPC1SCN4ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133504-A1 | METHOD OF TREATING GRAFT-VERSUS-HOST DISEASE | REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-05-04 | — | — | US | disclosed |
| US-20220185831-A1 | STAT3 PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185831-A1 | STAT3 PROTEIN DEGRADERS | STAT3, JAK2, STAT5A | LMNA 3655/4885NPC1 4173/4885SCN4A 2511/4885 |
| US-20230133504-A1 | METHOD OF TREATING GRAFT-VERSUS-HOST DISEASE | HLA-DRB1, CD74, HLA-C | LMNA 4779/4885NPC1 952/4885SCN4A 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.