Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447286 | 0.82 | POLB (0.44) | SMN1; SMN2LMNAPOLBMMP13MMP2 | |
| SCHEMBL2419233 | 0.80 | RBP4 (0.41) | SMN1; SMN2LMNAKDM4ECHRM2CHRM1 | |
| SCHEMBL2428188 | 0.79 | EED (0.54) | POLBKDM4EALDH1A1HTTEED | |
| SCHEMBL2454067 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2LMNAPOLBKDM4EMMP13 | |
| SCHEMBL2454613 | 0.79 | LMNA (0.41) | SMN1; SMN2LMNAPOLBKDM4EMMP13 | |
| SCHEMBL2454973 | 0.77 | CHRM2 (0.45) | SMN1; SMN2LMNAPOLBKDM4EMMP13 | |
| SCHEMBL2444427 | 0.77 | LMNA (0.44) | SMN1; SMN2LMNAPOLBKDM4EMMP13 | |
| SCHEMBL2278659 | 0.74 | TSHR (0.46) | SMN1; SMN2LMNAPOLBALDH1A1GAA | |
| SCHEMBL2446770 | 0.73 | FABP6 (0.38) | SMN1; SMN2LMNAPOLBKDM4ECYP1A2 | |
| SCHEMBL28225300 | 0.72 | BRD4 (0.57) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550252-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | Theravance, Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119461-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-09-29 | — | — | WO | disclosed |