Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 2/20 | 0.41 |
| ▸ | FABP6 | P51161 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | REV1 | Q9UBZ9 | 3/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453353 | 0.80 | SMN1; SMN2 (0.42) | RBP4MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL750673 | 0.79 | RBP4 (0.55) | RBP4MEN1KMT2ACCR5KDM4E | |
| SCHEMBL2418493 | 0.74 | ALDH1A1 (0.42) | RBP4MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL2417525 | 0.74 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5429190 | 0.73 | ALDH1A1 (0.46) | RBP4MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL3229083 | 0.71 | SLC9A1 (0.56) | RBP4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16212708 | 0.71 | EED (0.45) | RBP4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL17398128 | 0.70 | QDPR (0.45) | CCR5KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5439719 | 0.69 | REV1 (0.42) | RBP4CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3652239 | 0.69 | RBP4 (0.52) | RBP4MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550252-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | Theravance, Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119461-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-09-29 | — | — | WO | disclosed |