Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1259373 | 0.81 | LMNA (0.55) | CYP3A4ALOX15ALDH1A1KMT2AMEN1 | |
| SCHEMBL5666074 | 0.81 | LMNA (0.55) | CYP3A4ALOX15ALDH1A1KMT2AMEN1 | |
| SCHEMBL20981721 | 0.76 | ALDH1A1 (0.39) | RAB9AMTORGRM7TSHRCYP3A4 | |
| SCHEMBL20981722 | 0.75 | ALDH1A1 (0.38) | RAB9AMTORGRM7TSHRCYP3A4 | |
| SCHEMBL21496448 | 0.75 | ALDH1A1 (0.38) | RAB9AMTORGRM7TSHRCYP3A4 | |
| SCHEMBL27335011 | 0.75 | CYP2D6 (0.56) | TSHRCYP3A4ALOX15ALDH1A1TDP1 | |
| SCHEMBL21143280 | 0.75 | KMT2A (0.49) | TSHRATMALDH1A1KMT2AMEN1 | |
| SCHEMBL14769282 | 0.75 | MTOR (0.48) | RAB9AMTORGRM7TSHRCYP3A4 | |
| SCHEMBL5077174 | 0.75 | MTOR (0.65) | RAB9AMTORGRM7TSHRCYP3A4 | |
| SCHEMBL8095249 | 0.74 | MTOR (1.00) | RAB9AMTORGRM7TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022130411-A1 | SMAC MIMETICS FOR TREATMENT OF CANCER, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2022-06-23 | — | — | WO | disclosed |