Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8745114 | 0.82 | MAOB (0.38) | APPRAB9ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL8882137 | 0.82 | KCNA3 (0.52) | KCNH2KCNA3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8883515 | 0.80 | KCNA3 (0.56) | KCNH2KCNA3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2465787 | 0.78 | KCNH2 (0.52) | KCNH2KCNA3APPRAB9ASMN1; SMN2 | |
| SCHEMBL7634483 | 0.78 | TSHR (0.40) | — | |
| SCHEMBL10650830 | 0.76 | SMN1; SMN2 (0.50) | KCNH2APPSMN1; SMN2LMNAPTGS1 | |
| SCHEMBL9401075 | 0.76 | IDH1 (0.41) | KCNH2KCNA3APPRAB9ASMN1; SMN2 | |
| SCHEMBL15542484 | 0.74 | RXRA (0.48) | RAB9ASMN1; SMN2LMNAALDH1A1MAOB | |
| SCHEMBL216358 | 0.74 | — | — | |
| SCHEMBL9473450 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294699-B1 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORP (US) | 2016-04-13 | — | — | EP | claimed |
| US-8518999-B2 | Modulators of TNF-αsignaling | GENZYME CORPORATION (US) | 2013-08-27 | — | — | US | claimed |
| CN-100494182-C | Regulatory factor of tumor necrosis alpha factor | GENZYME CORP (US) | 2009-06-03 | — | — | CN | claimed |
| CN-1753673-A | Prodrugs of gaba analogs, compositions and uses thereof | XENOPORT INC (US) | 2006-03-29 | — | — | CN | claimed |
| US-6969728-B2 | Antiinflammatory agents | GENZYME CORPORATION (US) | 2005-11-29 | — | — | US | claimed |
| CN-1441787-A | Modulators of TNF-alpha signaling | GENZYME CORP (US) | 2003-09-10 | — | — | CN | claimed |
| EP-1294699-A2 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORPORATION (US) | 2003-03-26 | — | — | EP | claimed |
| US-20020119988-A1 | Antiinflammatory agents | GENZYME CORPORATION | 2002-08-29 | — | — | US | claimed |
| WO-2001087849-A2 | MODULATORS OF TNF- ALPHA SIGNALING | GENZYME CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |
| EP-0673923-B1 | Substituted phenoxymethyl-phenyl-derivatives, process for their preparation and their use as parasiticides and fungicides | BASF AG (DE) | 1998-05-20 | — | — | EP | claimed |
| US-5696161-A | Substituted phenoxymethylphenyl derivatives, their preparation and their use for controlling pests and fungi | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-09 | — | — | US | claimed |
| US-5545664-A | Substituted phenoxymethylphenyl derivatives, their preparation and their use for controlling pests and fungi | BASF AKTIENGESELLSCHAFT (DE) | 1996-08-13 | — | — | US | claimed |
| CN-1121510-A | Substituted phenoxymethylphenyl derivatives, their preparation and their use for controlling pests and fungi | BASF AG (DE) | 1996-05-01 | — | — | CN | claimed |
| EP-0365328-B1 | Pyridine derivatives | ZENECA LTD (GB) | 1996-04-03 | — | — | EP | claimed |
| US-5053415-A | Antiischemic, antiinflammatory, antiarthritic agents, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-10-01 | — | — | US | claimed |
| EP-0365328-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1990-04-25 | — | — | EP | claimed |
| US-4310658-A | Production of polyester thermally stabilized with an oxirane | ALLIED CORPORATION (US) | 1982-01-12 | — | — | US | claimed |
| EP-0042057-A1 | Production of polyester thermally stabilized with an oxirane | ALLIED CORPORATION (US) | 1981-12-23 | — | — | EP | claimed |
| US-11731954-B2 | Histone demethylase inhibitors | CELGENE QUANTICEL RES INC (US) | 2023-08-22 | — | — | US | disclosed |
| EP-0042057-A1 | Production of polyester thermally stabilized with an oxirane | ALLIED CORPORATION (US) | 1981-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731954-B2 | Histone demethylase inhibitors | KDM1B, KDM1A, BMI1 | KCNH2 3826/4885KCNA3 3817/4885APP 4531/4885 |
| US-20020119988-A1 | Antiinflammatory agents | TNF, TNFRSF1A, CD40 | KCNH2 4618/4885KCNA3 4778/4885APP 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.