Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24547906 | 1.00 | P2RX3 (0.31) | P2RX3P2RX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24541092 | 1.00 | P2RX3 (0.31) | P2RX3P2RX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24540925 | 0.80 | TRPV4 (0.38) | SLC6A3 | |
| SCHEMBL31043203 | 0.80 | TRPV4 (0.38) | SLC6A3 | |
| SCHEMBL24547910 | 0.80 | TRPV4 (0.38) | SLC6A3 | |
| SCHEMBL24540924 | 0.80 | TRPV4 (0.38) | SLC6A3 | |
| SCHEMBL24540773 | 0.79 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL24540771 | 0.79 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL24541226 | 0.79 | NPSR1 (0.35) | — | |
| SCHEMBL24541228 | 0.79 | NPSR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194955-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194955-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | P2RX3 4870/4885P2RX2 4868/4885SLC6A2 4781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.