Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24540924 | 1.00 | TRPV4 (0.38) | TRPV4CHRNB2CHRNA4HRH3HDAC4 | |
| SCHEMBL24540925 | 1.00 | TRPV4 (0.38) | TRPV4CHRNB2CHRNA4HRH3HDAC4 | |
| SCHEMBL31043203 | 1.00 | TRPV4 (0.38) | TRPV4CHRNB2CHRNA4HRH3HDAC4 | |
| SCHEMBL24541092 | 0.80 | P2RX3 (0.31) | SLC6A3 | |
| SCHEMBL24541093 | 0.80 | P2RX3 (0.31) | SLC6A3 | |
| SCHEMBL24547906 | 0.80 | P2RX3 (0.31) | SLC6A3 | |
| SCHEMBL24540920 | 0.79 | HTR2C (0.40) | — | |
| SCHEMBL23522762 | 0.79 | HTR2C (0.40) | — | |
| SCHEMBL23522761 | 0.79 | HTR2C (0.40) | — | |
| SCHEMBL24541182 | 0.78 | CHRNB2 (0.43) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |