Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 5/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24565773 | 0.81 | NAAA (0.37) | LTA4HTEAD3KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL24565775 | 0.78 | KCNJ6 (0.41) | TEAD3KCNJ6KCNJ5KCNJ3MAPK14 | |
| SCHEMBL24566834 | 0.75 | LTA4H (0.38) | LTA4HTEAD3ADORA2AADORA1TAAR1 | |
| SCHEMBL20413736 | 0.67 | POLB (0.46) | LTA4HSMN1; SMN2 | |
| SCHEMBL24007635 | 0.66 | MPO (0.36) | PKMNPC1LMNATP53RAB9A | |
| SCHEMBL31328912 | 0.64 | TEAD3 (0.41) | LTA4HTEAD3PKMHDAC3HDAC4 | |
| SCHEMBL25035706 | 0.63 | PKM (0.56) | LTA4HTEAD3PKMNPC1LMNA | |
| SCHEMBL21962128 | 0.63 | HDAC3 (0.54) | LTA4HTEAD3TAAR1HDAC3HDAC4 | |
| SCHEMBL20660877 | 0.63 | TEAD3 (0.43) | LTA4HTEAD3PKMHDAC3HDAC4 | |
| SCHEMBL1231223 | 0.63 | TSHR (0.40) | LTA4HMAPK14TAAR1PKMMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |