Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577224 | 0.77 | CYP11B2 (0.36) | — | |
| SCHEMBL24577874 | 0.75 | FLT3 (0.38) | KIT | |
| SCHEMBL24577152 | 0.75 | CREBBP (0.32) | — | |
| SCHEMBL24578878 | 0.69 | KDR (0.38) | ALDH1A1 | |
| SCHEMBL24578525 | 0.69 | BRAF (0.30) | — | |
| SCHEMBL24577085 | 0.66 | KIT (0.39) | KIT | |
| SCHEMBL24577471 | 0.64 | BACE1 (0.40) | — | |
| SCHEMBL24578564 | 0.62 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL16320750 | 0.60 | ALDH1A1 (0.44) | COMTALDH1A1KITSMN1; SMN2 | |
| SCHEMBL16320429 | 0.60 | ALDH1A1 (0.47) | COMTALDH1A1KITS1PR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |